Open AccessDesign and synthesis of ribonucleic guanidine: a polycationic analog of RNA.
Author(s) -
Robert O. Dempcy,
Jianyang Luo,
Thomas C. Bruice
Publication year - 1996
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.93.9.4326
Subject(s) - guanidine , phosphodiester bond , rna , chemistry , protein biosynthesis , stereochemistry , combinatorial chemistry , biochemistry , gene
Replacement of the phosphodiester linkages of the polyanion RNA with guanidinium linkers (represented by g) provides the polycation ribonucleic guanidine (RNG). An anticipated structure for the triple-helical hybrid [r(Up)9U.r(Ag)9A.r(Up)9U] is presented. A basic strategy for the synthesis of RNG oligomers is described. Synthetic procedures are provided for tetrameric adenosyl RNG [r(Ag)3A].