Cell fate determination in the vertebrate retina. | Zendy

Constance L. Cepko | Zendy; Christopher P. Austin | Zendy; Xian-Jie Yang | Zendy; Macrene Alexiades | Zendy; D. Ezzeddine | Zendy

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Cell fate determination in the vertebrate retina.

Author(s) -

Constance L. Cepko,

Christopher P. Austin,

Xian-Jie Yang,

Macrene Alexiades,

D. Ezzeddine

Publication year - 1996

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.93.2.589

Subject(s) - cell fate determination , retina , biology , vertebrate , neuroscience , progenitor cell , cell type , microbiology and biotechnology , cell , retinal , mitosis , stem cell , genetics , transcription factor , biochemistry , gene

In the vertebrate central nervous system, the retina has been a useful model for studies of cell fate determination. Recent results from studies conducted in vitro and in vivo suggest a model of retinal development in which both the progenitor cells and the environment change over time. The model is based upon the notion that the mitotic cells within the retina change in their response properties, or "competence", during development. These changes presage the ordered appearance of distinct cell types during development and appear to be necessary for the production of the distinct cell types. As the response properties of the cells change, so too do the environmental signals that the cells encounter. Together, intrinsic properties and extrinsic cues direct the choice of cell fate.

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