Open AccessP-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development.
Author(s) -
Daniel P. Szeto,
Aimee K. Ryan,
Shawn M. O’Connell,
Michael G. Rosenfeld
Publication year - 1996
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.93.15.7706
Subject(s) - pou domain , homeobox , anterior pituitary , biology , transactivation , pituitary gland , transcription factor , phenotype , microbiology and biotechnology , medicine , endocrinology , anatomy , gene , genetics , hormone
A novel OTX-related homeodomain transcription factor has been identified on the basis of its ability to interact with the transactivation domain of the pituitary-specific POU domain protein, Pit-1. This factor, referred to as P-OTX (pituitary OTX-related factor), is expressed in primordial Rathke's pouch, oral epithelium, first bronchial arch, duodenum, and hindlimb. In the developing anterior pituitary, it is expressed in all regions from which cells with distinct phenotypes will emerge in the mature gland. P-OTX is able to independently activate and to synergize with Pit-1 on pituitary-specific target gene promoters. Therefore, P-OTX may subserve functions in generating both precursor and specific cell phenotypes in the anterior pituitary gland and in several other organs.