Principles of protein-protein interactions. | Zendy

Susan R. Jones | Zendy; Janet M. Thornton | Zendy

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Principles of protein-protein interactions.

Author(s) -

Susan R. Jones,

Janet M. Thornton

Publication year - 1996

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.93.1.13

Subject(s) - protein–protein interaction , protein structure , protein crystallization , chemistry , biochemistry , biology , computational biology , organic chemistry , crystallization

This review examines protein complexes in the Brookhaven Protein Databank to gain a better understanding of the principles governing the interactions involved in protein-protein recognition. The factors that influence the formation of protein-protein complexes are explored in four different types of protein-protein complexes--homodimeric proteins, heterodimeric proteins, enzyme-inhibitor complexes, and antibody-protein complexes. The comparison between the complexes highlights differences that reflect their biological roles.

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