Open AccessA receptor guanylyl cyclase expressed specifically in olfactory sensory neurons.
Author(s) -
Hans-Jürgen Fülle,
Robert Vassar,
David C. Foster,
RueyBing Yang,
Richard Axel,
David L. Garbers
Publication year - 1995
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.92.8.3571
Subject(s) - olfactory receptor , biology , olfactory system , gucy2d , sensory system , microbiology and biotechnology , receptor , olfaction , soluble guanylyl cyclase , population , transmembrane domain , biochemistry , cyclase , guanylate cyclase 2c , neuroscience , guanylate cyclase , medicine , environmental health
We have cloned an additional member (GC-D) of the membrane receptor guanylyl cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] family that is specifically expressed in a subpopulation of olfactory sensory neurons. The extracellular, putative ligand-binding domain of the olfactory cyclase is similar in primary structure to two guanylyl cyclases expressed in the retina but diverges considerably from other known guanylyl cyclases. The expression of GC-D RNA is restricted to a small, randomly dispersed population of neurons that is within a single topographic zone in the olfactory neuroepithelium and resembles the pattern of the more diverse seven-transmembrane-domain odorant receptors. These observations suggest that GC-D may function directly in odor recognition or in modulating the sensitivity of a subpopulation of sensory neurons to specific odors.