Phospholipase D signaling is essential for meiosis. | Zendy

Kristine Rose | Zendy; Simon A. Rudge | Zendy; Michael A. Frohman | Zendy; Andrew J. Morris | Zendy; JoAnne Engebrecht | Zendy

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Phospholipase D signaling is essential for meiosis.

Author(s) -

Kristine Rose,

Simon A. Rudge,

Michael A. Frohman,

Andrew J. Morris,

JoAnne Engebrecht

Publication year - 1995

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.92.26.12151

Subject(s) - phosphatidic acid , phosphoinositide phospholipase c , phospholipase d , biology , signal transduction , second messenger system , phospholipase c , phospholipase , pld2 , microbiology and biotechnology , phosphatidylinositol , biochemistry , isozyme , gq alpha subunit , enzyme , phospholipid , g protein , membrane

Phospholipid metabolism plays an important role in cellular regulation by generating second messengers for signal transduction. Many stimuli activate a phospholipase D, which catalyzes the hydrolysis of phosphatidylcholine, producing phosphatidic acid and choline. Here we report that the yeast SP014 gene, which is essential for meiosis [Honigberg, S. M., Conicella, C. & Esposito, R. E. (1992) Genetics 130, 703-716], encodes a phospholipase D. SP014 RNA and protein activity are induced during late meiotic prophase, and the enzyme has properties similar to mammalian phosphatidylinositol 4,5-bisphosphate-regulated phospholipase D. Characterization of an unusual allele of SP014 defines regions of the protein important for enzyme catalysis and regulation. These results implicate phospholipase D signaling in regulating cellular differentiation.

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