Open AccessThe angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.
Author(s) -
Miki Nakajima,
Howard G. Hutchinson,
Masahiko Fujinaga,
Wataru Hayashida,
Ryuichi Morishita,
Lunan Zhang,
Masatsugu Horiuchi,
Richard E. Pratt,
Victor J. Dzau
Publication year - 1995
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.92.23.10663
Subject(s) - angiotensin ii receptor type 1 , angiotensin ii , receptor , insulin like growth factor 1 receptor , interleukin 1 receptor, type i , angiotensin receptor , interleukin 21 receptor , endocrinology , medicine , biology , microbiology and biotechnology , chemistry , growth factor
The type 1 angiotensin II (AT1) receptor is well characterized but the type 2 (AT2) receptor remains an enigma. We tested the hypothesis that the AT2 receptor can modulate the growth of vascular smooth muscle cells by transfecting an AT2 receptor expression vector into the balloon-injured rat carotid artery and observed that overexpression of the AT2 receptor attenuated neointimal formation. In cultured smooth muscle cells, AT2 receptor transfection reduced proliferation and inhibited mitogen-activated protein kinase activity. Furthermore, we demonstrated that the AT2 receptor mediated the developmentally regulated decrease in aortic DNA synthesis at the latter stages of gestation. These results suggest that the AT2 receptor exerts an antiproliferative effect, counteracting the growth action of AT1 receptor.