Evidence for two distinct retinoic acid response pathways for HOXB1 gene regulation. | Zendy

Toshihiko Ogura | Zendy; Ronald M. Evans | Zendy

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Evidence for two distinct retinoic acid response pathways for HOXB1 gene regulation.

Author(s) -

Toshihiko Ogura,

Ronald M. Evans

Publication year - 1995

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.92.2.392

Subject(s) - retinoic acid , coactivator , retinoid x receptor gamma , retinoic acid receptor , retinoid , biology , gene , regulation of gene expression , retinoid x receptor , retinoid x receptor beta , genetics , cancer research , microbiology and biotechnology , nuclear receptor , transcription factor

We have recently identified a promoter proximal retinoic acid (RA)-responsive site in the 5' region of the HOXB1 gene. In this report, we have identified the second RA-responsive site in the 3' region of the HOXB1 gene. This site also consists of a DR-2-type target of RA receptor.retinoid X receptor complex (DR-2B) and the binding site for a distinct RA-dependent coactivator termed retinoid-activating protein, which shows a different tissue-specific spectrum from the 5' responsive site. This indicates that the activation of the HOXB1 gene is achieved through two distinct pathways. These data define an unusual regulatory mechanism leading to the establishment of HOXB1 gene expression.

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