Open AccessThree-dimensional functional magnetic resonance imaging of human brain on a clinical 1.5-T scanner.
Author(s) -
Peter van Gelderen,
Nick F. Ramsey,
Guoying Liu,
J.H. Duyn,
Joseph A. Frank,
D.R. Weinberger,
Chrit Moonen
Publication year - 1995
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.92.15.6906
Subject(s) - functional magnetic resonance imaging , finger tapping , blood oxygenation , magnetic resonance imaging , scanner , human brain , functional magnetic resonance spectroscopy of the brain , nuclear magnetic resonance , brain activity and meditation , neuroscience , signal (programming language) , weighting , neuroimaging , motor cortex , brain mapping , computer science , physics , stimulation , artificial intelligence , medicine , psychology , electroencephalography , acoustics , radiology , programming language , audiology
Functional magnetic resonance imaging (fMRI) is a tool for mapping brain function that utilizes neuronal activity-induced changes in blood oxygenation. An efficient three-dimensional fMRI method is presented for imaging brain activity on conventional, widely available, 1.5-T scanners, without additional hardware. This approach uses large magnetic susceptibility weighting based on the echo-shifting principle combined with multiple gradient echoes per excitation. Motor stimulation, induced by self-paced finger tapping, reliably produced significant signal increase in the hand region of the contralateral primary motor cortex in every subject tested.
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