Open AccessA type 1 serine/threonine kinase receptor that can dorsalize mesoderm in Xenopus.
Author(s) -
Daniel Mahony,
J. B. Gurdon
Publication year - 1995
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.92.14.6474
Subject(s) - notochord , mesoderm , xenopus , fgf and mesoderm formation , biology , endoderm , nodal , ectoderm , microbiology and biotechnology , endocrinology , embryogenesis , embryo , genetics , cellular differentiation , embryonic stem cell , gene
We have cloned a type I serine/threonine kinase receptor, XTrR-I, from Xenopus. XTrR-I (Xenopus transforming growth factor beta-related receptor type I) is expressed in all regions of embryos throughout early development. Overexpression of this receptor does not affect ectoderm or endoderm but dorsalizes the mesoderm such that muscle appears in ventral mesoderm and notochord appears in lateral mesoderm normally fated to become muscle. In addition, overexpression of XTrR-I in UV-treated embryos is able to cause formation of a partial dorsal axis. These results suggest that XTrR-I encodes a receptor which responds in normal development to a transforming growth factor beta-like ligand so as to promote dorsalization. Its function would therefore be to direct mesodermalized tissue into muscle or notochord.
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