Open AccessA model of dendritic spine Ca2+ concentration exploring possible bases for a sliding synaptic modification threshold.
Author(s) -
Joshua I. Gold,
Mark F. Bear
Publication year - 1994
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.91.9.3941
Subject(s) - excitatory postsynaptic potential , postsynaptic potential , dendritic spine , biophysics , postsynaptic current , chemistry , kinetics , stimulation , inhibitory postsynaptic potential , synaptic plasticity , receptor , neuroscience , biology , biochemistry , physics , hippocampal formation , quantum mechanics
We used a biophysical model of an isolated dendritic spine to assess quantitatively the impact of changes in spine geometry, Ca2+ buffer concentration, and channel kinetics on Ca2+ dynamics following high-frequency activation of N-methyl-D-aspartate receptors. We found that varying the buffer concentration in the postsynaptic density from 50 to 500 microM can result in an 8-fold difference in the peak Ca2+ concentration following three pulses at 100 Hz. Similarly, varying the spine neck diameter from 0.1 to 0.55 micron can result in a 15-fold difference in the peak Ca2+ concentration. The amplification of peak Ca2+ concentration also depended on temporal summation of N-methyl-D-aspartate-mediated excitatory postsynaptic currents. Variation of the current duration on the order of 100 msec can significantly affect summation at a given stimulation frequency, resulting in a 10-fold difference in the peak Ca2+ concentration at 100 Hz. It is suggested that activity-dependent modifications of these parameters may be important for the regulation of synaptic plasticity in the brain.