Thermodynamic procedure to synthesize heteropolymers that can renature to recognize a given target molecule. | Zendy

Vijay S. Pande | Zendy; Alexander Y. Grosberg | Zendy; Toyoichi Tanaka | Zendy

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Thermodynamic procedure to synthesize heteropolymers that can renature to recognize a given target molecule.

Author(s) -

Vijay S. Pande,

Alexander Y. Grosberg,

Toyoichi Tanaka

Publication year - 1994

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.91.26.12976

Subject(s) - molecule , globular protein , biological system , yield (engineering) , polymer , computational biology , computer science , in vivo , combinatorial chemistry , chemistry , biology , physics , biochemistry , genetics , thermodynamics , organic chemistry

We suggest a procedure to synthesize polymers with characteristics similar to those observed in globular proteins: renaturability and the existence of an "active site" capable of specifically recognizing a given target molecule. This procedure is investigated by computer simulation, which finds a yield of up to 65%. We believe that, in principle, this scheme can be realized in vitro. The applicability of this approach as a model of prebiotic synthesis in vivo is also discussed.

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