Open AccessDNA recognition code of transcription factors in the helix-turn-helix, probe helix, hormone receptor, and zinc finger families.
Author(s) -
Masashi Suzuki,
Naoto Yagi
Publication year - 1994
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.91.26.12357
Subject(s) - zinc finger , dna , transcription factor , computational biology , helix (gastropod) , genetics , dna binding protein , helix turn helix , transcription (linguistics) , biology , base pair , hmg box , gene , ecology , linguistics , philosophy , snail
We have previously reported that in four transcription factor families the DNA-recognition rules can be described as (i) chemical rules, which list possible pairings between the 20 amino acid residues and the four DNA bases, and (ii) stereochemical rules, which describe the base and amino acid positions in contact. We have incorporated these rules into a computer program and examined the nature of the rules. Here we conclude that the DNA recognition rules are simple, logical, and consistent. The rules are specific enough to predict DNA-binding characteristics from a protein sequence.