Cerebrodiene: a brain lipid isolated from sleep-deprived cats. | Zendy

Richard A. Lerner | Zendy; Gary Siuzdak | Zendy; Óscar Prospéro-García | Zendy; Steven J. Henriksen | Zendy; Dale L. Boger | Zendy; Benjamin F. Cravatt | Zendy

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Cerebrodiene: a brain lipid isolated from sleep-deprived cats.

Author(s) -

Richard A. Lerner,

Gary Siuzdak,

Óscar Prospéro-García,

Steven J. Henriksen,

Dale L. Boger,

Benjamin F. Cravatt

Publication year - 1994

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.91.20.9505

Subject(s) - cats , sleep (system call) , degree of unsaturation , sphingosine , cerebrospinal fluid , chemistry , biology , biochemistry , endocrinology , medicine , chromatography , receptor , computer science , operating system

We report the isolation of a heretofore unrecognized brain lipid that is present in cerebrospinal fluid of sleep-deprived cats. The molecule appears to be a long-chain base structurally related to sphingosine and sphinganine in which a second unsaturated bond has been introduced. An increase in the degree of unsaturation of a key membrane component is expected to have important physiological consequences.

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