A cytolysin encoded by Salmonella is required for survival within macrophages. | Zendy

Stephen J. Libby | Zendy; Werner Goebel | Zendy; Andreas Ludwig | Zendy; N A Buchmeier | Zendy; Frances Bowe | Zendy; Ferric C. Fang | Zendy; D G Guiney | Zendy; J. Glenn Songer | Zendy; Fred Heffron | Zendy

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A cytolysin encoded by Salmonella is required for survival within macrophages.

Author(s) -

Stephen J. Libby,

Werner Goebel,

Andreas Ludwig,

N A Buchmeier,

Frances Bowe,

Ferric C. Fang,

D G Guiney,

J. Glenn Songer,

Fred Heffron

Publication year - 1994

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.91.2.489

Subject(s) - cytolysin , biology , microbiology and biotechnology , salmonella , virulence , enterobacteriaceae , hemolysis , hemolysin , escherichia coli , shigella , shigella boydii , gene , genetics , bacteria , immunology

A Salmonella gene encoding a cytolysin has been identified by screening for hemolysis on blood agar. DNA sequence analyses together with genetic mapping in Salmonella suggest that it is unrelated to other toxins or hemolysins. The gene (slyA) is present in every strain of Salmonella examined, in Shigella, and in enteroinvasive Escherichia coli but not in other Enterobacteriaceae. SlyA (salmolysin) purified from a derivative of the original clone has hemolytic and cytolytic activity and has a molecular weight predicted by the DNA sequence. The median lethal dose and infection kinetics in mice suggest that the toxin is required for virulence and facilitates Salmonella survival within mouse peritoneal macrophages.

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