Open AccessHuman and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily.
Author(s) -
Chawnshang Chang,
S L Da Silva,
Ritsuro Ideta,
Y Lee,
Shuyuan Yeh,
J. P. H. Burbach
Publication year - 1994
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.91.13.6040
Subject(s) - orphan receptor , neuron derived orphan receptor 1 , gpr18 , biology , estrogen related receptor gamma , nuclear receptor , receptor , rhodopsin like receptors , genetics , microbiology and biotechnology , metabotropic receptor , transcription factor , gene , agonist , cannabinoid receptor
We have identified a member of the steroid receptor superfamily and cloned it from human and rat hypothalamus, prostate, and testis cDNA libraries. The open reading frame between first ATG and terminator TGA can encode 615 (human) and 596 (rat) amino acids with calculated molecular mass of 67.3 (human) and 65.4 (rat) kDa. The amino acid sequence of this protein, called TR4 orphan receptor, is closely related to the previously identified TR2 orphan receptor. The high homology between TR2 and TR4 orphan receptor suggests that these two orphan receptors constitute a unique subfamily within the steroid receptor superfamily. These two orphan receptors are differentially expressed in rat tissues. Unlike TR2 orphan receptors, the TR4 orphan receptor appears to be predominantly located in granule cells of the hippocampus and the cerebellum, suggesting that it may play some role(s) in transcriptional regulation in these neurons.