Dynamic instability of microtubules as an efficient way to search in space. | Zendy

Timothy E. Holy | Zendy; Stanislas Leibler | Zendy

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Dynamic instability of microtubules as an efficient way to search in space.

Author(s) -

Timothy E. Holy,

Stanislas Leibler

Publication year - 1994

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.91.12.5682

Subject(s) - prometaphase , instability , microtubule , mitosis , biophysics , biological system , physics , computer science , biology , cell , microbiology and biotechnology , mechanics , cell cycle , genetics , anaphase

During the formation of the mitotic spindle, dynamic microtubules search for chromosomes in the surrounding cytosol. The average time required to reach such "targets" is calculated within a simple model of dynamic instability. The values of the dynamic parameters that minimize this search time are also obtained. The results approximate well observations of the capture of chromosomes in prometaphase cells. Compared to usual reversible polymerization, dynamic instability reduces the time required to find a target by several orders of magnitude.

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