Open AccessBST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth.
Author(s) -
Tsuneyasu Kaisho,
Jun Ishikawa,
K Oritani,
Johji Inazawa,
H. Tomizawa,
Osamu Muraoka,
T. Ochi,
Tomoko Hirano
Publication year - 1994
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.91.12.5325
Subject(s) - stromal cell , bone marrow , cell culture , lymphopoiesis , lymph node stromal cell , b cell , biology , microbiology and biotechnology , haematopoiesis , cd38 , cell growth , stem cell , chemistry , immunology , cancer research , antibody , cd34 , biochemistry , genetics
Bone marrow stromal cells are essential for B-lymphocyte development. However, how stromal cells regulate B lymphopoiesis is not clear. In this paper, we report the molecular cloning of a stromal cell line-derived glycosyl-phosphatidylinositol-anchored molecule, BST-1, that facilitates pre-B-cell growth. The deduced amino acid sequence of BST-1 exhibited 33% identity with CD38. BST-1 was expressed in a wide range of tissues and in umbilical vein endothelial cells, whereas it was scarcely expressed in a variety of hematopoietic cell lines. The gene for BST-1 was assigned to chromosome 14q32.3, where immunoglobulin heavy-chain genes are clustered. BST-1 expression was enhanced in rheumatoid arthritis patient-derived bone marrow stromal cell lines that were previously shown to have an enhanced ability to support the growth of a pre-B-cell line as compared with stromal cell lines derived from healthy donors.
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