Open AccessLoss of function of the Drosophila zfh-1 gene results in abnormal development of mesodermally derived tissues.
Author(s) -
Z C Lai,
Emma Rushton,
Michael Bate,
Gerald M. Rubin
Publication year - 1993
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.90.9.4122
Subject(s) - homeobox , mesoderm , biology , zinc finger , loss function , genetics , gene , phenotype , mutant , lim domain , function (biology) , embryonic stem cell , mutation , cell fate determination , microbiology and biotechnology , gene expression , transcription factor
The Drosophila zfh-1 gene encodes an unusual protein with nine Cys2His2 type zinc-finger motifs and one homeodomain that shows a complex pattern of expression in the embryonic mesoderm and nervous system. To study the function of zfh-1, we generated loss-of-function zfh-1 mutations. Phenotypic analysis of zfh-1 mutant embryos reveals that the gene is not required for the initial segregation of the mesoderm or for the differentiation of mesodermally derived tissues. Rather, loss of zfh-1 function results in various degrees of local errors in cell fate or positioning.
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