Developmental expression of the platelet-derived growth factor alpha-receptor gene in mammalian central nervous system. | Zendy

HoMing Yeh | Zendy; Inmaculada SilosSantiago | Zendy; Y X Wang | Zendy; Ravisundar George | Zendy; William D. Snider | Zendy; Thomas F. Deuel | Zendy

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Developmental expression of the platelet-derived growth factor alpha-receptor gene in mammalian central nervous system.

Author(s) -

HoMing Yeh,

Inmaculada SilosSantiago,

Y X Wang,

Ravisundar George,

William D. Snider,

Thomas F. Deuel

Publication year - 1993

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.90.5.1952

Subject(s) - biology , platelet derived growth factor receptor , in situ hybridization , platelet derived growth factor , paracrine signalling , gene expression , central nervous system , microbiology and biotechnology , neuroglia , growth factor , receptor , regulation of gene expression , embryonic stem cell , endocrinology , gene , genetics

We recently reported that the platelet-derived growth factor (PDGF) A-chain gene is highly expressed in neurons of embryonic and adult mouse central nervous system and suggested that its secretion by neurons may support development and maintenance of glia. We have now analyzed the levels and sites of expression of the cognate PDGF alpha-receptor gene in brain and spinal cord of embryonic and adult mice by in situ hybridization. The predominant cell populations in both gray and white matter expressing transcripts of the PDGF alpha-receptor gene are glial cells or their precursors. Transcripts consistently were not detected in neurons. Expression of the PDGF alpha-receptor gene was first observed at embryonic day 15, increased through postnatal day 14, and fell to lower levels in adults. Expression of the alpha-receptor gene corresponds in temporal sequence to the developmental period of glial migration and proliferation and to the expression of PDGF A by neurons. The results indicate that glia but not neurons have the potential to respond to PDGF A and suggest that neurons influence glial cell development through paracrine regulation.

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