Open AccessMEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex.
Author(s) -
Dana Leifer,
Dimitri Krainc,
YiTao Yu,
John C. McDermott,
Roger E. Breitbart,
John Heng,
Rachael L. Neve,
Barry E. Kosofsky,
B Nadal-Ginard,
Stuart A. Lipton
Publication year - 1993
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.90.4.1546
Subject(s) - mef2 , transcription factor , agamous , mef2c , biology , mads box , enhancer , gene isoform , cerebral cortex , serum response factor , microbiology and biotechnology , neuroscience , genetics , gene , arabidopsis , mutant , homeotic gene
We have cloned cDNA encoding a human transcription factor that belongs to the MEF2 (myocyte-specific enhancer-binding factor 2) subfamily of the MADS (MCM1-agamous-deficiens-serum response factor) gene family. This factor, which we have named MEF2C, binds specifically to the MEF2 element and activates transcription via this element. Specific isoforms of this factor are found exclusively in brain and are robustly expressed by neurons in cerebral cortex. In situ hybridization indicates that the factor is expressed preferentially in certain neuronal layers of cortex and that expression declines during postnatal development. The unusual pattern of expression in brain suggests that this transcription factor may be important in the development of cortical architecture.
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