Open AccessRegional cerebral glucose metabolism in late-life depression and Alzheimer disease: a preliminary positron emission tomography study.
Author(s) -
A Kumar,
Andrew B. Newberg,
Abass Alavi,
Jesse A. Berlin,
Robin J. Smith,
M. Reivich
Publication year - 1993
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.90.15.7019
Subject(s) - positron emission tomography , depression (economics) , late life depression , alzheimer's disease , disease , carbohydrate metabolism , medicine , glucose uptake , fluorodeoxyglucose , psychology , neuroscience , cardiology , insulin , economics , hippocampal formation , macroeconomics
Eight subjects with late-life depression, eight subjects with probable Alzheimer disease, and eight healthy age-matched controls were studied using 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography in the resting state with their eyes open and ears unoccluded. The depressed subjects showed widespread reductions in the regional cerebral metabolic rate for glucose in most major neocortical, subcortical, and paralimbic regions that were significantly different from control values (P < 0.01). The metabolic decrements in the depressed group were comparable in magnitude to those seen in the Alzheimer disease group. These data demonstrate widespread nonfocal decline in glucose metabolism in late-life depression that is comparable to the hypometabolism seen in Alzheimer disease. These findings have pathophysiological implications in major depressive disorder in the elderly.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom