Stable growth transformation of human T lymphocytes by herpesvirus saimiri. | Zendy

Brigitte Biesinger | Zendy; Ingrid MüllerFleckenstein | Zendy; B. Simmer | Zendy; G Lang | Zendy; Sabine Wittmann | Zendy; E Platzer | Zendy; Ronald C. Desrosiers | Zendy; Bernhard Fleckenstein | Zendy

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Stable growth transformation of human T lymphocytes by herpesvirus saimiri.

Author(s) -

Brigitte Biesinger,

Ingrid MüllerFleckenstein,

B. Simmer,

G Lang,

Sabine Wittmann,

E Platzer,

Ronald C. Desrosiers,

Bernhard Fleckenstein

Publication year - 1992

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.89.7.3116

Subject(s) - biology , virology , virus , cd8 , phenotype , genome , transformation (genetics) , in vitro , cell culture , t cell , immunology , genetics , gene , immune system

Herpesvirus saimiri induces T-cell lymphomas in various species of New World monkeys and in rabbits, and it is able to immortalize monkey T lymphocytes in vitro. Sequences responsible for these effects have been localized to a region of the genome that varies significantly among the virus subgroups A, B, and C. We now report that infection of human blood lymphocytes and thymocytes with strains of subgroup C, in contrast to viruses of the other subgroups, yields continuously proliferating T-cell lines with the phenotype of mature CD4- or CD8-positive cells. Infection with strains of Herpes-virus saimiri subgroup C can thus be used to generate human T-cell lines for a variety of immunological and developmental studies.

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