Open AccessSpatial pattern of receptor expression in the olfactory epithelium.
Author(s) -
Patrick Nef,
Irm HermansBorgmeyer,
Helene Artieres-Pin,
Lora Beasley,
Vincent E. Dionne,
Stephen F. Heinemann
Publication year - 1992
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.89.19.8948
Subject(s) - olfactory epithelium , olfactory receptor , receptor , olfactory system , olfaction , biology , microbiology and biotechnology , odor , olfactory mucosa , transmembrane protein , neuroscience , genetics
A PCR-based strategy for amplifying putative receptors involved in murine olfaction was employed to isolate a member (OR3) of the seven-transmembrane-domain receptor superfamily. During development, the first cells that express OR3 appear adjacent to the wall of the telencephalic vesicle at embryonic day 10. The OR3 receptor is uniquely expressed in a subset of olfactory cells that have a characteristic bilateral symmetry in the adult olfactory epithelium. This receptor and its specific pattern of expression may serve a functional role in odor coding or, alternatively, may play a role in the development of the olfactory system.