Open AccessSelection-induced mutations occur in yeast.
Author(s) -
Barry G. Hall
Publication year - 1992
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.89.10.4300
Subject(s) - saccharomyces cerevisiae , biology , genetics , selection (genetic algorithm) , escherichia coli , locus (genetics) , yeast , point mutation , mutation , saccharomyces , gene , artificial intelligence , computer science
Selection-induced mutations are nonrandom mutations that occur as specific and direct responses to environmental challenges and primarily in nondividing cells under conditions of intense prolonged selection. Selection-induced mutations have been shown to occur at six loci in Escherichia coli, but their existence has not previously been demonstrated in any eukaryotic organism. Here it is shown that selection-induced mutations occur at the HIS4 locus in the eukaryotic microorganism Saccharomyces cerevisiae.