UGA is translated as cysteine in pheromone 3 of Euplotes octocarinatus. | Zendy

F. Meyer | Zendy; Helmut Schmidt | Zendy; Evelyn Plümper | Zendy; Andrej Hasilík | Zendy; G. Mersmann | Zendy; Helmut E. Meyer | Zendy; Annie Engström | Zendy; Klaus Heckmann | Zendy

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UGA is translated as cysteine in pheromone 3 of Euplotes octocarinatus.

Author(s) -

F. Meyer,

Helmut Schmidt,

Evelyn Plümper,

Andrej Hasilík,

G. Mersmann,

Helmut E. Meyer,

Annie Engström,

Klaus Heckmann

Publication year - 1991

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.88.9.3758

Subject(s) - release factor , stop codon , biology , genetics , cysteine , transfer rna , gene , biochemistry , rna , enzyme

Pheromone 3 mRNA of the ciliate Euplotes octocarinatus contains three in-frame UGA codons that are translated as cysteines. This was revealed from cDNA sequencing and from plasma desorption mass spectrometry of cleaved pheromone 3 in connection with pyridylethylation of the fragments. N-terminal sequence analysis of carboxymethylated protein confirmed this conclusion for the first of the three UGA codons. Besides UGA the common cysteine codons UGU and UGC are also used to encode cysteine. UAA functions as a termination codon. No UAG codon was found. In connection with results reported for other ciliates, this suggests that the role of the classic termination codons had not yet been established when the ciliates started to diverge from other eukaryotes.

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