Open AccessCoordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells.
Author(s) -
Rocco J. Rotello,
R. Lieberman,
Anthony F. Purchio,
L. E. Gerschenson
Publication year - 1991
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.88.8.3412
Subject(s) - cell growth , apoptosis , microbiology and biotechnology , transforming growth factor, beta 3 , transforming growth factor , transforming growth factor beta , programmed cell death , growth factor , cell culture , biology , cell , tgf alpha , receptor , biochemistry , genetics
Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation.