Open AccessInterleukin 4 promotes expression of mast cell ICAM-1 antigen.
Author(s) -
Peter Valent,
Dorian Bevec,
Dieter Maurer,
J Besemer,
Franco Di Padova,
J. H. Butterfield,
Wolfgang Speiser,
Otto Majdic,
Klaus Lechner,
Peter Bettelheim
Publication year - 1991
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.88.8.3339
Subject(s) - mast cell , microbiology and biotechnology , immune system , antigen , interleukin 33 , biology , monocyte , cytokine , antigen presentation , immunology , interleukin , t cell
Cell recognition molecules play a crucial role in the regulation of immune cells. We recently found that mast cells (MCs) express leukocyte recognition molecules, including ICAM-1 antigen, a natural ligand of LFA-1. We here report that interleukin 4 (IL-4), a pleiotropic cytokine and mast cell differentiation factor, selectively promotes expression of surface ICAM-1 antigen and ICAM-1 mRNA in human MCs. IL-4 also up-regulates ICAM-1 antigen in cells of monocyte/macrophage lineage but has no effect on ICAM-1 antigen expressed on basophils, fibroblasts, or lymphocytes. The increase in expression of mast cell/macrophage ICAM-1 antigen induced by IL-4 may contribute to the accumulation of leukocytes and facilitate cell-contact-dependent regulation of immune cells in inflamed tissues.