The small subunit of transcription factor IIF recruits RNA polymerase II into the preinitiation complex. | Zendy

Osvaldo Flores | Zendy; Hua Lu | Zendy; Marie T. Killeen | Zendy; Jack Greenblatt | Zendy; Zachary F. Burton | Zendy; Danny Reinberg | Zendy

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The small subunit of transcription factor IIF recruits RNA polymerase II into the preinitiation complex.

Author(s) -

Osvaldo Flores,

Hua Lu,

Marie T. Killeen,

Jack Greenblatt,

Zachary F. Burton,

Danny Reinberg

Publication year - 1991

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.88.22.9999

Subject(s) - transcription factor ii f , transcription factor ii d , transcription factor ii a , transcription preinitiation complex , transcription factor ii e , rna polymerase ii , iif , microbiology and biotechnology , rna polymerase ii holoenzyme , general transcription factor , sigma factor , polymerase , rna polymerase i , transcription factor ii b , biology , transcription (linguistics) , rna polymerase , rna dependent rna polymerase , rna , promoter , genetics , dna , gene , gene expression , linguistics , philosophy , antibody , autoantibody

We found that transcription factor IIF mediates the association of RNA polymerase II with promoter sequences containing transcription factors IID, IIB, and IIA (DAB complex). The resulting DNA-protein complex contained RNA polymerase II and the two subunits of transcription factor IIF (RAP 30 and RAP 74). Cloned human RAP 30 was sufficient for the recruitment of RNA polymerase II to the DAB complex. This ability of RAP 30 to recruit RNA polymerase to a promoter is also a characteristic of sigma factors in prokaryotes.

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