Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats. | Zendy

Una McKeever | Zendy; J P Mordes | Zendy; Dale L. Greiner | Zendy; Michael Appel | Zendy; Jan Rozing | Zendy; Eugene S. Handler | Zendy; A A Rossini | Zendy

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Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats.

Author(s) -

Una McKeever,

J P Mordes,

Dale L. Greiner,

Michael Appel,

Jan Rozing,

Eugene S. Handler,

A A Rossini

Publication year - 1990

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.87.19.7618

Subject(s) - insulitis , adoptive cell transfer , autoimmunity , immunology , spleen , autoimmune thyroiditis , diabetes mellitus , thyroiditis , medicine , major histocompatibility complex , immune system , biology , endocrinology , t cell , thyroid

We describe the induction of autoimmune diabetes, insulitis, and thyroiditis in athymic rats following injections of major histocompatibility complex compatible spleen cells. Lymphocytes with these capabilities were found in normal rats of the YOS, WAG, PVG, and diabetes-resistant BB strains, and in diabetes-prone BB rats. Adoptive transfer was facilitated by prior in vivo depletion of RT6.1+ regulatory T cells and in vitro mitogen activation of donor spleen cells. By RT6 depleting diabetes-resistant donors and using nude recipients, transfer of diabetes and thyroiditis was accomplished by using fresh, unstimulated spleen cells. The data suggest that organ-specific autoreactive cells may be present to various degrees but suppressed to a variable extent in many rat strains. The equilibrium between autoreactive and regulatory cells appears to determine the expression of autoimmunity.

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