Promotion of wound repair in old mice by local injection of macrophages. | Zendy

D. Da | Zendy; Mary Ann Kowatch | Zendy; G. S. Roth | Zendy

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Promotion of wound repair in old mice by local injection of macrophages.

Author(s) -

D. Da,

Mary Ann Kowatch,

G. S. Roth

Publication year - 1989

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.86.6.2018

Subject(s) - macrophage , wound healing , senescence , promotion (chess) , immunology , medicine , biology , microbiology and biotechnology , biochemistry , in vitro , politics , political science , law

Application of peritoneal macrophages to experimentally induced cutaneous wounds of old mice accelerates healing to levels almost comparable to those of untreated young animals. Slightly greater acceleration is observed when macrophages are obtained from young as opposed to old donors. These findings are consistent with a defect in macrophage function as a cause of impaired wound healing in senescence and suggest a possible therapeutic strategy.

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