Open AccessDuplication of large genomic regions during the evolution of vertebrate homeobox genes.
Author(s) -
Klaus Schughart,
Claudia Kappen,
F.H. Ruddle
Publication year - 1989
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.86.18.7067
Subject(s) - homeobox , antennapedia , homeobox a1 , homeobox protein nkx 2.5 , gene duplication , hnf1b , gene , genetics , biology , gene cluster , phylogenetic tree , vertebrate , gene expression
The phylogenetic relationships of 21 murine Antp-class (Drosophila mutation Antennapedia-type class) homeobox genes have been analyzed, and several groups of related genes have been identified. The murine Antp-class homeobox genes are localized within four gene clusters. The similar structural organization of the four gene clusters strongly suggests that genes within a group of related Antp-class homeobox genes are derived from duplications of large genomic regions. After the duplication, the gross structures of the homeobox gene clusters have been maintained over a long period of evolutionary time, indicating that the specific organization of genes within a cluster may be of functional importance.
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