Adenylate cyclase mediates olfactory transduction for a wide variety of odorants. | Zendy

Graeme Lowe | Zendy; Tadashi Nakamura | Zendy; Geoffrey H. Gold | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Adenylate cyclase mediates olfactory transduction for a wide variety of odorants.

Author(s) -

Graeme Lowe,

Tadashi Nakamura,

Geoffrey H. Gold

Publication year - 1989

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.86.14.5641

Subject(s) - cyclase , adenylate kinase , forskolin , odor , olfactory epithelium , transduction (biophysics) , stimulation , biology , second messenger system , signal transduction , olfaction , biochemistry , endocrinology , microbiology and biotechnology , chemistry , olfactory system , medicine , neuroscience , enzyme

An odor-stimulated adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] is thought to mediate olfactory transduction in vertebrates. However, it is not known whether the adenylate cyclase serves this function for all odorants or for only certain classes of odorants. To investigate this question, we have compared the abilities of 35 odorants to stimulate the adenylate cyclase and to elicit an electrophysiological response. We report a strong positive correlation between the magnitude of adenylate cyclase stimulation and the summated electrical response of the olfactory epithelium (electro-olfactogram) evoked by individual odorants. We also show that the adenylate cyclase stimulator forskolin equally attenuates the electro-olfactogram response for all odorants tested. These data provide evidence that the adenylate cyclase mediates transduction for a wide variety of odorants.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research