Open AccessSeveral distinct "CCAAT" box binding proteins coexist in eukaryotic cells.
Author(s) -
Michel Raymondjean,
Silvia Cereghini,
Moshe Yaniv
Publication year - 1988
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.85.3.757
Subject(s) - caat box , ccaat enhancer binding proteins , transcription factor , binding site , promoter , biology , transcription (linguistics) , microbiology and biotechnology , dna binding protein , consensus sequence , binding protein , physics , peptide sequence , genetics , gene , gene expression , linguistics , philosophy
Even though a "CCAAT" box element is localized approximately equal to 80 base pairs upstream of the transcription initiation site in many eukaryotic promoters, it is not recognized by a single ubiquitous transcription factor. We show here that such a sequence present in the rat albumin promoter binds a protein distinct from the CCAAT-binding transcription factor CTF/NFI or from the CCAAT-binding protein (CBP) previously described. The protein binding to the albumin CCAAT sequence (ACF or albumin CCAAT factor) is not exclusive to liver, since we found a protein with identical properties in spleen.