Open AccesscDNA encoding the glycosyl-phosphatidylinositol-specific phospholipase C of Trypanosoma brucei.
Author(s) -
Dale Hereld,
Gerald W. Hart,
Paul T. Englund
Publication year - 1988
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.85.23.8914
Subject(s) - trypanosoma brucei , biology , complementary dna , lipase , biochemistry , phospholipase c , glycoprotein , phosphatidylinositol , expression cloning , membrane glycoproteins , glycosyl , membrane protein , gene , enzyme , membrane , signal transduction
VSG lipase of Trypanosoma brucei specifically cleaves the glycosyl-phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein (VSG), releasing this protein from the plasma membrane. It also cleaves similar membrane anchors on some mammalian proteins. VSG lipase may play a role in processes such as parasite differentiation or antigenic variation. We describe here the cloning and sequencing of a cDNA encoding VSG lipase from T. brucei.
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