Cloning and characterization of a dispersed, multicopy, X chromosome sequence in Drosophila melanogaster. | Zendy

Gail L. Waring | Zendy; Jonathan Pollack | Zendy

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Cloning and characterization of a dispersed, multicopy, X chromosome sequence in Drosophila melanogaster.

Author(s) -

Gail L. Waring,

Jonathan Pollack

Publication year - 1987

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.84.9.2843

Subject(s) - biology , genetics , euchromatin , drosophila melanogaster , chromosome , sequence (biology) , chromosome 4 , polytene chromosome , dna , melanogaster , sequence analysis , microbiology and biotechnology , heterochromatin , gene

We have isolated and characterized a dispersed middle repetitive DNA sequence from Drosophila melanogaster that is concentrated on the euchromatic portion of the X chromosome. In situ hybridization of the repeat unit to salivary gland chromosomes shows the sequence is distributed among approximately 10 major and 20 minor X chromosomal sites. Based on DNA sequence analysis of homologous sequences from three different cytogenetic regions, the 372-base-pair repeat unit appears to be (A + T)-rich and noncoding and shows strong sequence conservation among units from different chromosomal regions. The nature and distribution of this sequence are suggestive of the hypothetical X chromosome DNA sequences thought to be involved in the primary establishment of sex determination and dosage compensation in Drosophila.

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