Open AccessActivation of pp60c-src protein kinase activity in human colon carcinoma.
Author(s) -
Joseph B. Bolen,
André Veillette,
Arnold M. Schwartz,
V DeSeau,
Neal Rosen
Publication year - 1987
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.84.8.2251
Subject(s) - proto oncogene tyrosine protein kinase src , tyrosine kinase , biology , protein kinase a , kinase , tyrosine , colon carcinoma , carcinoma , microbiology and biotechnology , cancer research , biochemistry , signal transduction , colorectal cancer , cancer , genetics
The tyrosine-specific protein kinase activity of pp60c-src molecules obtained from human colon carcinoma tissues and tumor-derived cell lines was found to be elevated over that from normal colon tissues or cultures of normal colon mucosal cells. The elevated pp60c-src protein kinase activity in tumor tissues and in cultured colon carcinoma cells does not appear to result solely from an increase in the abundance of the c-src-encoded protein, suggesting that the specific activity of the pp60c-src tyrosine phosphotransferase is enhanced. These results raise the possibility that activation of the pp60c-src protein kinase may contribute to the genesis of human colon tumors.