Mapping the X-linked lymphoproliferative syndrome. | Zendy

James Skare | Zendy; Aubrey Milunsky | Zendy; Kevin Byron | Zendy; J L Sullivan | Zendy

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Mapping the X-linked lymphoproliferative syndrome.

Author(s) -

James Skare,

Aubrey Milunsky,

Kevin Byron,

J L Sullivan

Publication year - 1987

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.84.7.2015

Subject(s) - lymphoproliferative disorders , restriction fragment length polymorphism , locus (genetics) , mononucleosis , haplotype , biology , genetics , x chromosome , microbiology and biotechnology , virus , immunology , genotype , lymphoma , gene

The X-linked lymphoproliferative syndrome is triggered by Epstein-Barr virus infection and results in fatal mononucleosis, immunodeficiency, and lymphoproliferative disorders. This study shows that the mutation responsible for X-linked lymphoproliferative syndrome is genetically linked to a restriction fragment length polymorphism detected with the DXS42 probe (from Xq24-q27). The most likely recombination frequency between the loci is 4%, and the associated logarithm of the odds is 5.26. Haplotype analysis using flanking restriction fragment length polymorphism markers indicates that the locus for X-linked lymphoproliferative syndrome is distal to probe DXS42 but proximal to probe DXS99 (from Xq26-q27). It is now possible to predict which members of a family with X-linked lymphoproliferative syndrome are carrier females and to diagnose the syndrome prenatally.

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