Open AccessIdentification of a monoclonal antibody specific for a murine T3 polypeptide.
Author(s) -
Oberdan Léo,
M Foo,
David H. Sachs,
Lawrence E. Samelson,
Jeffrey A. Bluestone
Publication year - 1987
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.84.5.1374
Subject(s) - monoclonal antibody , microbiology and biotechnology , clone (java method) , cytolysis , antigen , biology , t cell , antibody , cell , chemistry , biochemistry , gene , immune system , in vitro , immunology , cytotoxic t cell
A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific for a 25-kDa protein component (T3-epsilon) of the antigen-specific T-cell receptor. It reacts with all mature T cells and can both activate and inhibit T-cell function. These results identify T3-epsilon as a cell surface protein involved in the transduction of activation signals.