Open AccessOn the translocation of proteins across membranes.
Author(s) -
S. J. Singer,
Pamela Maher,
Michael P. Yaffe
Publication year - 1987
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.84.4.1015
Subject(s) - cytoplasm , organelle , mechanism (biology) , membrane , chromosomal translocation , chemistry , intracellular , microbiology and biotechnology , biophysics , computational biology , biology , biochemistry , physics , gene , quantum mechanics
Many proteins of intracellular organelles are first synthesized in the cytoplasm and are then specifically transferred across the membranes of the organelles. On the assumption that these transfers all occur by the same basic mechanism, we enumerate the rather stringent requirements that the mechanism must satisfy. A unitary molecular mechanism is then proposed that meets these requirements.