Bacteriophage T4 regA protein binds to mRNAs and prevents translation initiation. | Zendy

Robert B. Winter | Zendy; L. A. Morrissey | Zendy; Peter Gauss | Zendy; Larry Gold | Zendy; Tien Hsu | Zendy; J.D. Karam | Zendy

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Bacteriophage T4 regA protein binds to mRNAs and prevents translation initiation.

Author(s) -

Robert B. Winter,

L. A. Morrissey,

Peter Gauss,

Larry Gold,

Tien Hsu,

J.D. Karam

Publication year - 1987

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.84.22.7822

Subject(s) - bacteriophage , ribosome , repressor , translation (biology) , messenger rna , biology , ribosomal binding site , start codon , psychological repression , gene , protein biosynthesis , eukaryotic translation , microbiology and biotechnology , genetics , gene expression , rna , escherichia coli

The bacteriophage T4 regA protein is a translational repressor of a subset of phage mRNAs. We show here that purified regA protein binds specifically to target mRNAs near the initiating AUG and occludes binding of ribosomes. Translational repression by regA protein diminishes expression of many genes whose mRNA sequences around the initiating AUG codons are different. A comparison of nucleotide sequences from several regA-repressed mRNAs suggests that the initiating AUG is an important, but not sufficient, sequence for regA binding.

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