A pancreas specificity results from the combination of polyomavirus and Moloney murine leukemia virus enhancer. | Zendy

Rosemary Rochford | Zendy; B A Campbell | Zendy; Luis P. Villarreal | Zendy

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A pancreas specificity results from the combination of polyomavirus and Moloney murine leukemia virus enhancer.

Author(s) -

Rosemary Rochford,

B A Campbell,

Luis P. Villarreal

Publication year - 1987

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.84.2.449

Subject(s) - murine leukemia virus , enhancer , biology , recombinant dna , virology , leukemia , genome , virus , microbiology and biotechnology , gene , genetics , transcription factor

An infectious recombinant polyomavirus was constructed in which a regulatory region of its genome, the B enhancer region (nucleotides 5128-5265) has been replaced with the 72- or 73-base-pair repeat enhancer from the Moloney murine leukemia virus genome. We show that this recombinant polyomavirus displays a strong tissue specificity for the pancreas of mice. This organ was not permissive for either the parental polyomavirus, which is predominantly kidney and salivary gland specific, or the Moloney murine leukemia virus, which is lymphotropic. This result indicated that tissue specificity can be achieved by a combination of apparently modular elements. Some of the implications of a modular mechanism of tissue specificity are considered.

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