Open AccessInterleukin 4 (B-cell stimulatory factor 1) can enhance or antagonize the factor-dependent growth of hemopoietic progenitor cells.
Author(s) -
D Rennick,
Gloria Yang,
Christa E. MüllerSieburg,
Colton Smith,
Naoko Arai,
Yosinobu Takabe,
L Gemmell
Publication year - 1987
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.84.19.6889
Subject(s) - progenitor cell , interleukin 3 , haematopoiesis , microbiology and biotechnology , biology , stromal cell , stem cell factor , stem cell , growth factor , bone marrow , immunology , cancer research , t cell , biochemistry , antigen presenting cell , receptor , immune system
Our studies show that although interleukin 4 (IL-4) fails to stimulate significant colony formation by bone marrow progenitor cells, it enhances erythroid, granulocyte, macrophage, and mast-cell colony formation when used as a costimulant with erythropoietin, granulocyte colony-stimulating factor, macrophage colony-stimulating factor, and interleukin 3 (IL-3), respectively. In contrast, IL-4 suppresses IL-3-dependent colony formation by granulocyte and macrophage progenitor cells and by multipotential progenitor cells. Furthermore, it appears to inhibit the in vitro generation of colony-forming progenitor cells from immature IL-3-dependent stem cells. We also found that IL-4 inhibits stromal cell-dependent growth of bone marrow-derived pre-B cells. The ability of IL-4 to directly or indirectly regulate both positive and negative aspects of progenitor cell growth is discussed.
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