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We have used the giant ciliary comb plates of ctenophores to record electrical activity directly from cilia. A compound action potential was recorded extracellularly over most of the length of the comb plate cilia in response to electrical stimulation of the ectodermal nerve net. The ciliary action potential was correlated with intracellularly recorded action potentials, selectively blocked by Ca2+-channel antagonists, and correlated with ciliary reorientation and reversed beating. Dual-electrode recording from different sites on the same comb plate showed that, unlike protistan cilia, the approximately 1-mm-long cilia of comb plates are not isopotential. Rather, action potentials are generated 150-200 microns from the base and propagate to the tip of the cilia. These results indicate that voltage-dependent channels that mediate increases in intraciliary Ca2+ concentration are distributed over most of the length of the cilia. Consequently, the Ca2+-sensitive machinery controlling ciliary motor responses is also likely to be located along the length of the axoneme.

A calcium regenerative potential controlling ciliary reversal is propagated along the length of ctenophore comb plates.