Gated currents in isolated olfactory receptor neurons of the larval tiger salamander. | Zendy

Stuart Firestein | Zendy; F. Werblin | Zendy

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Gated currents in isolated olfactory receptor neurons of the larval tiger salamander.

Author(s) -

Stuart Firestein,

F. Werblin

Publication year - 1987

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.84.17.6292

Subject(s) - olfactory receptor cell , biophysics , receptor potential , potassium , voltage clamp , chemistry , olfactory receptor , current clamp , cardiac transient outward potassium current , patch clamp , sensory receptor , depolarization , membrane potential , stimulus (psychology) , electrophysiology , reversal potential , inward rectifier potassium ion channel , neuroscience , ion channel , biology , receptor , biochemistry , psychology , organic chemistry , psychotherapist

The electrical properties of enzymatically isolated olfactory receptor cells were studied with whole-cell patch clamp. Voltage-dependent currents could be separated into three ionic components: a transient inward sodium current, a sustained inward calcium current, and an outward potassium current. Three components of the outward current could be identified by their gating and kinetics: a calcium-dependent potassium current [IK(Ca)], a voltage-dependent potassium current [IK(V)], and a transient potassium current (Ia). Typical resting potentials were near -54 mV, and typical input resistance was 3-6 G omega. Thus, only 3 pA of injected current was required to depolarize the cell to spike threshold near -45 mV. The response to a current step consisted of either a single spike regardless of stimulus strength, or a train of less than 8 spikes, decrementing in amplitude and frequency over approximately equal to 250 msec. Thus, the receptor response cannot be finely graded with stimulus intensity.

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