Open AccessMacrophages specifically regulate the concentration of their own growth factor in the circulation.
Author(s) -
A. Bartocci,
Dimitrios Mastrogiannis,
Graziella Migliorati,
Richard J. Stockert,
Allan W. Wolkoff,
E Stanley
Publication year - 1987
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.84.17.6179
Subject(s) - endocytosis , mononuclear phagocyte system , macrophage , clearance , growth factor , microbiology and biotechnology , macrophage colony stimulating factor , chemistry , receptor , phagocyte , clearance rate , biology , phagocytosis , endocrinology , immunology , biochemistry , in vitro , medicine , urology
The physiological mechanism of clearance of the mononuclear phagocyte growth factor, colony-stimulating factor 1 (CSF-1), from the circulation of normal mice was investigated by following the fate of a trace amount of i.v. injected 125I-labeled CSF-1. Macrophages selectively cleared CSF-1 by CSF-1 receptor-mediated endocytosis and degraded the growth factor intracellularly. This manner of clearance provides a feedback control mechanism whereby the rate of macrophage production is determined by the number of mature macrophages.