Control of cytochrome P1-450 gene expression: analysis of a dioxin-responsive enhancer system. | Zendy

Phil Jones | Zendy; L K Durrin | Zendy; Donna R. Galeazzi | Zendy; James P. Whitlock | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Control of cytochrome P1-450 gene expression: analysis of a dioxin-responsive enhancer system.

Author(s) -

Phil Jones,

L K Durrin,

Donna R. Galeazzi,

James P. Whitlock

Publication year - 1986

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.83.9.2802

Subject(s) - enhancer , heterologous , biology , transfection , response element , gene , microbiology and biotechnology , cytochrome , promoter , gene expression , genetics , biochemistry , enzyme

We analyzed the function and sequence of a dioxin-responsive genomic element flanking the 5' end of the cytochrome P1-450 gene in high-activity variant mouse hepatoma cells. The element can regulate the mouse mammary tumor virus promoter. The element retains responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) when the distance, the 5' or 3' position, and/or the 5' or 3' orientation with respect to the promoter are varied. The function of the element requires TCDD-receptor complexes. The element remains responsive to TCDD when transfected into cells from either a heterologous mouse tissue or a heterologous species (human). The DNA element and TCDD receptors together constitute a dioxin-responsive enhancer system.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research