Open AccessFc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes.
Author(s) -
Fabio Malavasi,
Ciro Tetta,
Ada Funaro,
Graziella Bellone,
Enza Ferrero,
Anna Franzone,
Paolo Dellabona,
R Rusci,
Lina Matera,
Giovanni Camussi
Publication year - 1986
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.83.8.2443
Subject(s) - receptor , monoclonal antibody , microbiology and biotechnology , chemistry , cell surface receptor , platelet activation , immunology , platelet , biology , antibody , biochemistry
Triggering of large granular lymphocyte (LGL) Fc receptor with a specific monoclonal antibody (AB8.28) linked to an insoluble matrix induces cell activation, as witnessed by expression of HLA class II (DR and DQ) molecules and interleukin 2 receptor. Moreover, this event is accompanied by a concomitant release of platelet-activating factor by LGL. We conclude that the Fc receptor molecule identified by mAb AB8.28 represents a trigger for LGL activation.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom