Open AccessGenes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.
Author(s) -
Thomas A. Spies,
Cynthia C. Morton,
Sergei A. Nedospasov,
Walter Fiers,
Donald Pious,
Jack L. Strominger
Publication year - 1986
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.83.22.8699
Subject(s) - major histocompatibility complex , human leukocyte antigen , histocompatibility , biology , beta (programming language) , gene , chromosome , genetics , southern blot , microbiology and biotechnology , in situ hybridization , alpha (finance) , antigen , gene expression , medicine , computer science , programming language , construct validity , nursing , patient satisfaction
The human major histocompatibility complex (MHC) includes the closely linked genes for the tumor necrosis factors alpha and beta. Their location is within the chromosomal segment between HLA-DR and HLA-A or centromeric of HLA-DP. This assignment is based on Southern blot analysis of a number of different MHC deletion mutants and is corroborated by chromosome in situ hybridization.