Open AccessEvidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma.
Author(s) -
Jeffrey M. Trent,
Paul S. Meltzer,
Mark L. Rosenblum,
Griffith R. Harsh,
Kenneth W. Kinzler,
Robert Mashal,
Andrew P. Feinberg,
Bert Vogelstein
Publication year - 1986
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.83.2.470
Subject(s) - gene duplication , glioblastoma , gene , biology , proto oncogenes , oncogene , gene expression , cancer research , gene rearrangement , proto oncogene proteins c myc , microbiology and biotechnology , genetics , cell cycle
Amplified cellular genes are frequently manifested in one of two cytologically recognizable forms, double minutes or homogeneously staining regions. Additionally, evidence is accumulating that aberrant expression of cellular genes (including oncogenes) may be mediated by gene amplification. We now describe the amplification and expression of the cellular oncogene c-myc in double-minute-containing cells from a patient with glioblastoma multiforme, and we have shown that the amplification is associated with rearrangement of the c-myc gene. This finding further supports the common association of the myc gene family in neurogenic tumors and provides evidence of myc gene amplification in human brain cancer.